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Specialist Freeze-Drying for Sensitive Materials

Freeze-drying, or lyophilization, removes water from sensitive materials under reduced pressure and controlled temperature. Inovix Biosciences treats every cycle as project-specific: defined around the individual material and formulation, not applied as a single universal recipe.

A Multi-Stage Process

01

Freezing

The material is cooled until fully solidified. Freezing rate and end temperature influence ice structure, which affects drying behavior and the physical form of the finished cake.

02

Primary Drying

Under reduced pressure, frozen water is removed directly from solid to vapor. Shelf temperature and chamber pressure are controlled to remove the bulk of the water without collapsing the structure.

03

Secondary Drying

Remaining bound water is reduced under higher temperature and low pressure, to reach a defined target residual moisture appropriate for the material.

What Each Cycle Depends On

Freeze-drying is project-specific. The following characteristics are considered during assessment before a cycle is defined:

Formulation and excipients
Material concentration
Container and cake geometry
Freezing behavior
Thermal properties
Chamber pressure
Shelf temperature
Drying duration
Closure and packaging

Freeze-drying is a physical processing step. It does not, by itself, guarantee stability, sterility or any regulatory status. Suitability and outcomes depend on the specific material and formulation, and are evaluated on a project basis.

Have a material you are considering for freeze-drying?

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